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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CENPE All Species: 9.09
Human Site: S2664 Identified Species: 16.67
UniProt: Q02224 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q02224 NP_001804.2 2701 316415 S2664 P V R Y F D N S S L G L C P E
Chimpanzee Pan troglodytes XP_001170168 2701 316707 S2664 P V R Y F D N S S L G L C P E
Rhesus Macaque Macaca mulatta XP_001110512 2701 316828 S2664 P V R Y F D N S N L G L C P E
Dog Lupus familis XP_852631 1216 141588 K1180 T K E R N D L K E L Q E S F E
Cat Felis silvestris
Mouse Mus musculus Q6RT24 2474 286506 D2437 P H P I R Y F D N S S L G L C
Rat Rattus norvegicus Q7TSP2 1385 159522 H1349 L I G H Q N L H Q K I Q Y V V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_420670 2150 248600 L2114 N F F D N S N L S T L T D T Q
Frog Xenopus laevis NP_001080954 2954 339950 N2890 K Q Q K V Q E N L N S P K G K
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524993 2013 231091 G1977 G I M T D P V G M S S C S V F
Honey Bee Apis mellifera XP_001121311 1418 164919 I1382 R L K E L E E I Q S S F S L K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_781622 2537 290578 E2480 P L K D C N T E H P G I A R S
Poplar Tree Populus trichocarpa XP_002308893 1247 142380 N1211 E L A F M N R N Y E V A S K K
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_187629 1348 152938 I1312 M E A L S T L I S R R N R G D
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.7 95.7 37.8 N.A. 60.5 21.2 N.A. N.A. 37.1 31 N.A. N.A. 26.1 24.8 N.A. 25.5
Protein Similarity: 100 99.2 98 42 N.A. 75 35.7 N.A. N.A. 55 52.2 N.A. N.A. 45.6 37.8 N.A. 48.8
P-Site Identity: 100 100 93.3 20 N.A. 13.3 0 N.A. N.A. 13.3 0 N.A. N.A. 0 0 N.A. 13.3
P-Site Similarity: 100 100 100 20 N.A. 20 20 N.A. N.A. 20 20 N.A. N.A. 6.6 26.6 N.A. 40
Percent
Protein Identity: 23.9 N.A. N.A. 24.9 N.A. N.A.
Protein Similarity: 34.6 N.A. N.A. 37.6 N.A. N.A.
P-Site Identity: 0 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 33.3 N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 16 0 0 0 0 0 0 0 0 8 8 0 0 % A
% Cys: 0 0 0 0 8 0 0 0 0 0 0 8 24 0 8 % C
% Asp: 0 0 0 16 8 31 0 8 0 0 0 0 8 0 8 % D
% Glu: 8 8 8 8 0 8 16 8 8 8 0 8 0 0 31 % E
% Phe: 0 8 8 8 24 0 8 0 0 0 0 8 0 8 8 % F
% Gly: 8 0 8 0 0 0 0 8 0 0 31 0 8 16 0 % G
% His: 0 8 0 8 0 0 0 8 8 0 0 0 0 0 0 % H
% Ile: 0 16 0 8 0 0 0 16 0 0 8 8 0 0 0 % I
% Lys: 8 8 16 8 0 0 0 8 0 8 0 0 8 8 24 % K
% Leu: 8 24 0 8 8 0 24 8 8 31 8 31 0 16 0 % L
% Met: 8 0 8 0 8 0 0 0 8 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 16 24 31 16 16 8 0 8 0 0 0 % N
% Pro: 39 0 8 0 0 8 0 0 0 8 0 8 0 24 0 % P
% Gln: 0 8 8 0 8 8 0 0 16 0 8 8 0 0 8 % Q
% Arg: 8 0 24 8 8 0 8 0 0 8 8 0 8 8 0 % R
% Ser: 0 0 0 0 8 8 0 24 31 24 31 0 31 0 8 % S
% Thr: 8 0 0 8 0 8 8 0 0 8 0 8 0 8 0 % T
% Val: 0 24 0 0 8 0 8 0 0 0 8 0 0 16 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 24 0 8 0 0 8 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _